Associations between Comorbid TDP-43, Lewy Body Pathology and Neuropsychiatric Symptoms in Alzheimer's Disease

Authors

• Ece Bayram, Cleveland Clinic Lou Ruvo Center for Brain HealthFollow
• Guogen Shan, University of Nevada, Las VegasFollow
• Jeffrey L. Cummings, University of Nevada, Las VegasFollow

Document Type

Abstract

Publication Date

6-18-2019

Publication Title

Journal of Alzheimer's Disease

Volume

69

Issue

4

First page number:

953

Last page number:

961

Abstract

More than half of the patients with Alzheimer’s disease (AD) have comorbidities including TDP-43 and Lewy bodies, which are also associated with frontotemporal lobar degeneration and dementia with Lewy bodies, respectively. These comorbidities may help explain the overlapping neuropsychiatric symptoms between AD and other dementias. Data on 221 AD patients with Neuropsychiatric Inventory-Questionnaire were obtained from the National Alzheimer’s Coordinating Center. TDP-43 was associated with aberrant motor activity, whereas Lewy bodies were associated with anxiety, irritability, sleep behavior, and appetite problems. The associations between these comorbidities and neuropsychiatric symptoms were more significant for patients with sparse diffuse plaques.

Keywords

Alzheimer's Disease, Lewy body; Neuropsychiatric symptoms: TDP-43

Disciplines

Cognitive Neuroscience | Mental Disorders | Nutritional Epidemiology

File Format

PDF

File Size

111 KB

Language

English

Rights

IN COPYRIGHT. For more information about this rights statement, please visit http://rightsstatements.org/vocab/InC/1.0/

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License

Repository Citation

Bayram, E., Shan, G., Cummings, J. L. (2019). Associations between Comorbid TDP-43, Lewy Body Pathology and Neuropsychiatric Symptoms in Alzheimer's Disease. Journal of Alzheimer's Disease, 69(4), 953-961.
http://dx.doi.org/10.3233/JAD-181285