Document Type
Article
Publication Date
10-19-2021
Publication Title
PLOS One
Volume
16
Issue
10
First page number:
1
Last page number:
11
Abstract
Failure to thrive (FTT) impairs the expected normal physical growth of children. This study aimed to evaluate the effects of cyproheptadine hydrochloride on growth parameters in prepubertal children with FTT. The medical records of prepubertal children who were newly diagnosed with FTT at China Medical University Hospital between 2007 and 2016 were retrospectively examined. The patients were divided into two groups depending on whether they had (T-group) or had not (NT-group) received cyproheptadine hydrochloride (0.3 mg/kg daily) for at least 14 days. The mean length of the treatment period was 97.22 days (range: 14–532 days). Weight, height, and body mass index were adjusted for age using the median values in the growth charts for Taiwanese boys and girls as the reference. A total of 788 patients aged 3–11 years were enrolled, 50 in the T-group and 738 in the NT-group. No statistically significant difference in the median age-adjusted weight value was noted between the T-group and NT-group during the follow up period. In the T-group, age-adjusted weight and body mass index were inversely associated with age (P < 0.001, P < 0.001) and positively associated with medication duration (P = 0.026, P = 0.04). Our findings underscore the positive association between cyproheptadine hydrochloride treatment and weight gain among prepubertal children. Further prospective clinical studies with a. longer and consistent treatment course is warranted.
Keywords
Weight gain; body weight; charts; children; pediatrics; body mass index; medical conditions; puberty
Disciplines
Growth and Development
File Format
File Size
1065 KB
Language
English
Rights
IN COPYRIGHT. For more information about this rights statement, please visit http://rightsstatements.org/vocab/InC/1.0/
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Repository Citation
Lin, Y.,
Yen, H.,
Tsai, F.,
Wang, C.,
Chien, L.,
Chen, A.,
Lin, R.
(2021).
Effects of Cyproheptadine on Body Weight Gain in Children With Nonorganic Failure To Thrive in Taiwan: A Hospital-Based Retrospective Study.
PLOS One, 16(10),
1-11.
Available at:
http://dx.doi.org/10.1371/journal.pone.0258731