Carbon Ion Radiotherapy in the Management of Hepatocellular Carcinoma

Authors

• Belal Abousaida, Mayo Clinic Florida, Jacksonville
• Danushka Seneviratne, Mayo Clinic Florida, Jacksonville
• Bradford S. Hoppe, Mayo Clinic Florida, Jacksonville
• Stephen J. Ko, Mayo Clinic Florida, Jacksonville
• Aroumougame Asaithamby, University of Texas Southwestern Medical Center, Dallas
• Francis A. Cucinotta, University of Las Vegas, Las VegasFollow
• Jessica M. Kirwan, University of Florida, Gainesville
• Kabir Mody, Department of Internal Medicine, Mayo Clinic Florida
• Beau Toskich, Department of Radiology, Mayo Clinic Florida
• Jonathan B. Ashman, Mayo Clinic Arizona, Phoenix
• Christopher L. Hallemeier, Mayo Clinic Rochester, Rochester
• Sunil Krishnan, Mayo Clinic Florida, Jacksonville

Document Type

Article

Publication Date

9-24-2021

Publication Title

Journal of Hepatocellular Carcinoma

Volume

8

First page number:

1169

Last page number:

1179

Abstract

Localized hepatocellular carcinoma (HCC) that is unresectable and non-transplantable can be treated by several liver-directed therapies. External beam radiation therapy (EBRT) is an increasingly accepted and widely utilized treatment modality in this setting. Accelerated charged particles such as proton beam therapy (PBT) and carbon ion radiation therapy (CIRT) offer technological advancements over conventional photon radiotherapy. In this review, we summarize the distinct advantages of CIRT use for HCC treatment, focusing on physical and biological attributes, and outline dosimetric and treatment planning caveats. Based on these considerations, we posit that HCC may be among the best indications for use of CIRT, as it allows for maximizing tumoricidal doses to the target volume while minimizing the dose to the organs at risk.

Keywords

carbon ion therapy; hepatocellular carcinoma; hypofractionation

Disciplines

Radiology

File Format

PDF

File Size

433 KB

Rights

IN COPYRIGHT. For more information about this rights statement, please visit http://rightsstatements.org/vocab/InC/1.0/

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License

Repository Citation

Abousaida, B., Seneviratne, D., Hoppe, B. S., Ko, S. J., Asaithamby, A., Cucinotta, F. A., Kirwan, J. M., Mody, K., Toskich, B., Ashman, J. B., Hallemeier, C. L., Krishnan, S. (2021). Carbon Ion Radiotherapy in the Management of Hepatocellular Carcinoma. Journal of Hepatocellular Carcinoma, 8 1169-1179.
http://dx.doi.org/10.2147/JHC.S292516