Apolipoprotein-Defined Lipoprotein Subclasses, Serum Apolipoproteins, and Carotid Intima-Media Thickness in T1D

Authors

• Arpita Basu, University of Nevada, Las VegasFollow
• Alicia J. Jenkins, University of Sydney
• Julie A. Stoner, University of Oklahoma Health Sciences Center
• Ying Zhang, University of Oklahoma Health Sciences Center
• Richrd L. Klein, Medical University of South Carolina

Document Type

Article

Publication Date

3-25-2018

Publication Title

Journal of Lipid Research

Volume

59

Issue

5

First page number:

872

Last page number:

883

Abstract

Circulating apolipoprotein-defined lipoprotein subclasses (ADLS) and apolipoproteins predict vascular events in the general and type 2 diabetes populations, but data in T1D are limited. We examined associations of ADLS, serum apolipoproteins, and conventional lipids with carotid intima-media thickness (IMT) measured contemporaneously and 6 years later in 417 T1D participants [men: n = 269, age 42 +/- 6 y (mean +/- SD); women: n = 148, age 39 +/- 8 y] in the Epidemiology of Diabetes Interventions and Complications study, the follow-up of the Diabetes Control and Complications Trial (DCCT). Date were analyzed by multiple linear regression stratified by sex, and adjusted for time-averaged hemoglobin A1C, diabetes duration, hypertension, BMI, albuminuria, DCCT randomization, smoking, statin treatment, and ultrasound devices. In cross-sectional analyses, lipoprotein B (Lp-B), Lp-B:C, Lp-B:E+Lp-B:C:E, Apo-A-II, Apo-B, Apo-C-III-HP (heparin precipitate; i.e., Apo-C-III in Apo-B-containing lipoproteins), and Apo-E were positively associated with common and/or internal carotid IMT in men, but only Apo-C-III (total) was (positively) associated with internal carotid IMT in women. In prospective analyses, Lp-B, Apo-B, and Apo-C-III-HP were positively associated with common and/or internal carotid IMT in men, while Lp-A1:AII and Apo-A1 were inversely associated with internal carotid IMT in women. The only significant prospective association between conventional lipids and IMT was between triacylglycerols and internal carotid IMT in men. ADLS and apolipoprotein concentrations may provide sex-specific biomarkers and suggest mechanisms for IMT in people with T1D.

Keywords

Apolipoprotein B; Apolipoprotein-A-I; Apolipoprotein-C-III carotid intima-media thickness; Type 1 diabetes

Disciplines

Biostatistics | Endocrinology | Human and Clinical Nutrition | Internal Medicine | Nutritional Epidemiology | Pediatrics

File Format

PDF

File Size

155 KB

Language

English

Rights

IN COPYRIGHT. For more information about this rights statement, please visit http://rightsstatements.org/vocab/InC/1.0/

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Repository Citation

Basu, A., Jenkins, A. J., Stoner, J. A., Zhang, Y., Klein, R. L. (2018). Apolipoprotein-Defined Lipoprotein Subclasses, Serum Apolipoproteins, and Carotid Intima-Media Thickness in T1D. Journal of Lipid Research, 59(5), 872-883.
http://dx.doi.org/10.1194/jlr.P080143