Document Type

Poster

Publication Date

2-27-2026

Publication Title

Health Sciences Research Symposium

Publisher

University of Nevada, Las Vegas

Publisher Location

Las Vegas (Nev.)

Abstract

Background: Circadian rhythms regulate physiological and metabolic functions across a 24-hour cycle. However, modern lifestyles often disrupt these rhythms. A common example is weekend schedule shifts, when people sleep and wake later than on weekdays, a phenomenon referred to as social jetlag (SJL).

Purpose: The purpose of this study was to; 1) determine whether chronic SJL leads to impaired glucose tolerance, and 2) determine if acute changes in glucose tolerance occur following a weekend of social jetlag (SJL).

Methods: Fifteen male C57BL/6 mice on a normal chow diet were used in this study. To model social jetlag (SJL), mice were exposed to a weekend schedule shift by four hours (n = 5), or kept on a control schedule (CON; n = 10). Glucose tolerance testing (GTT) was conducted at baseline and > 10 weeks later by administering an intraperitoneal (IP) injection of a glucose solution prepared in saline, and following blood glucose for 2 hours. SJL mice were also tested on a Friday (before weekend shift) and Monday (after weekend shift), with testing sessions occurring one week apart in a counterbalanced design.

Results: SJL led to an increase in the GTT AUC and iAUC compared to baseline levels, while mice in the CON cohort showed no significant change. GTT AUC were not different on Monday and Friday, although Monday GTT’s showed a greater 30 minute peak in blood glucose.

Conclusion: Social Jetlag results in impaired glucose tolerance in a chronic (i.e. – a cumulative effect over many weeks) and an acute manner (changes in glucose tolerance over the week following SJL). This could have implications for metabolic health and testing.

Keywords

Social jetlag; Glucose tolerance test; exercise

Disciplines

Biochemical Phenomena, Metabolism, and Nutrition | Kinesiology | Other Kinesiology

File Format

PDF

File Size

927 KB

Language

English

Rights

IN COPYRIGHT. For more information about this rights statement, please visit http://rightsstatements.org/vocab/InC/1.0/

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