Document Type
Article
Publication Date
4-15-2022
Publication Title
Schizophrenia
First page number:
1
Last page number:
6
Abstract
Negative symptoms are commonly assessed via clinical rating scales; however, these measures have several inherent limitations that impact validity and utility for their use in clinical trials. Objective digital phenotyping measures that overcome some of these limitations are now available. The current study evaluated the validity of accelerometry (ACL), a passive digital phenotyping method that involves collecting data on the presence, vigor, and variability of movement. Outpatients with schizophrenia (SZ: n = 50) and demographically matched healthy controls (CN: n = 70) had ACL continuously recorded from a smartphone and smartband for 6 days. Active digital phenotyping assessments, including surveys related to activity context, were also collected via 8 daily surveys throughout the 6 day period. SZ participants had lower scores on phone ACL variables reflecting vigor and variability of movement compared to CN. ACL variables demonstrated convergent validity as indicated by significant correlations with active digital phenotyping self-reports of time spent in goal-directed activities and clinical ratings of negative symptoms. The discriminant validity of ACL was demonstrated by low correlations with clinical rating scale measures of positive, disorganized, and total symptoms. Collectively, findings suggest that ACL is a valid objective measure of negative symptoms that may complement traditional approaches to assessing the construct using clinical rating scales.
Keywords
Psychosis; Schizophrenia
Disciplines
Astrophysics and Astronomy
File Format
File Size
414 KB
Language
English
Rights
IN COPYRIGHT. For more information about this rights statement, please visit http://rightsstatements.org/vocab/InC/1.0/
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Repository Citation
Strauss, G. P.,
Raugh, I. M.,
Zhang, L.,
Luther, L.,
Chapman, H. C.,
Allen, D. N.,
Kirkpatrick, B.,
Cohen, A. S.
(2022).
Validation of Accelerometry as a Digital Phenotyping Measure of Negative Symptoms in Schizophrenia.
Schizophrenia
1-6.
http://dx.doi.org/10.1038/s41537-022-00241-z