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Description

The hippocampus has known roles in memory formation, learning, and spatial mapping. There are defined physiological differences between CA1 neurons based on their dorsal to ventral position within the 3D hippocampus (Malik et al., 2015). Given the varying functions of the dorsal and ventral hippocampus in cognitive processing and the role of the dentate gyrus as the entry point for information into the hippocampus, it will be interesting to determine if there are differences in the properties of granule cells across the dorsal and ventral axis. We explore the potential topographic specialization of dentate granule cells. This study examines the relationship between the neurophysiology of granule cells in the mouse dentate gyrus and their dorsal/ventral position in the hippocampus. Forty-four mouse hippocampi were sampled and assessed for dorsal/ventral position, spike train frequency, resting membrane potential, and action potential threshold. Using an established mapping algorithm for the rodent hippocampus, we mapped hippocampal slices for their dorsal/ventral position. Our sampling covers a range from very ventral to intermediate dorsal hippocampus. Physiological properties of CA1 cells display a linear relationship with their dorsal/ventral position. Therefore, we used linear regression to map the physiological parameters of dentate granule cells with their calculated dorsal and ventral position. We found that the physiological properties of dentate granule cells, unlike CA1 neurons, did not vary with their dorsal/ventral position within the hippocampus. Future experiments will record properties of dentate granule cells from the most dorsal location to complete the dorsal/ventral extent.

Publisher Location

Las Vegas (Nev.)

Publication Date

Fall 11-21-2025

Publisher

University of Nevada, Las Vegas

Language

English

Keywords

Hippocampus; Mice; Dentate Granule Cells; Neurophysiology; Dorsal/Ventral

Disciplines

Life Sciences | Neuroscience and Neurobiology

File Format

PDF

File Size

842 KB

Permissions

Google Drive\Institutional Repository\OUR_OfficeOfUGResearch\Symposia\2025 Fall Symposium

Comments

Mentor: Darrin Brager

Rights

IN COPYRIGHT. For more information about this rights statement, please visit http://rightsstatements.org/vocab/InC/1.0/

Dorsal/Ventral Orientation of Dentate Granule Cells and its Impact on Electrophysiology in Mice


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